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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
E2F1
All Species:
16.97
Human Site:
S375
Identified Species:
31.11
UniProt:
Q01094
Number Species:
12
Phosphosite Substitution
Charge Score:
0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q01094
NP_005216.1
437
46920
S375
P
V
D
E
D
R
L
S
P
L
V
A
A
D
S
Chimpanzee
Pan troglodytes
XP_524538
437
47536
P380
S
M
L
E
L
P
H
P
L
L
Q
Q
T
E
D
Rhesus Macaque
Macaca mulatta
XP_001103717
502
53768
S440
P
V
D
E
D
R
L
S
P
L
V
A
A
D
S
Dog
Lupus familis
XP_542963
571
61192
S509
P
V
D
E
D
R
L
S
P
L
V
A
A
D
S
Cat
Felis silvestris
Mouse
Mus musculus
Q61501
430
46305
S368
P
M
E
E
D
Q
L
S
P
L
V
A
A
D
S
Rat
Rattus norvegicus
Q62814
300
33206
E246
F
Q
Q
T
P
A
T
E
I
S
S
G
S
I
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515449
468
50133
E398
C
C
D
P
P
K
L
E
L
P
G
S
L
L
D
Chicken
Gallus gallus
Q90977
403
43534
T349
S
P
L
A
S
M
D
T
L
L
E
H
G
K
D
Frog
Xenopus laevis
NP_001090608
426
47125
P366
D
Y
T
L
N
C
L
P
L
S
P
S
D
L
L
Zebra Danio
Brachydanio rerio
NP_001074097
429
46452
S375
S
P
L
S
S
S
L
S
S
I
L
Q
Q
P
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q27368
805
87442
A713
G
G
G
Y
G
S
I
A
G
A
G
A
N
A
D
Honey Bee
Apis mellifera
XP_396223
416
46049
S362
P
S
I
E
S
S
L
S
T
R
L
C
T
P
V
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_001123287
404
44387
D350
K
A
T
A
L
E
E
D
D
L
S
A
L
S
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
40.7
86
70.9
N.A.
84.6
23.1
N.A.
39.9
59.9
49.8
37.2
N.A.
20.6
29.7
N.A.
38.4
Protein Similarity:
100
54.4
86.2
72.6
N.A.
88.5
37.9
N.A.
51.2
70
63.3
53.7
N.A.
31.5
46.4
N.A.
54.2
P-Site Identity:
100
13.3
100
100
N.A.
80
6.6
N.A.
13.3
6.6
6.6
13.3
N.A.
6.6
26.6
N.A.
13.3
P-Site Similarity:
100
26.6
100
100
N.A.
100
13.3
N.A.
26.6
13.3
20
26.6
N.A.
20
33.3
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
16
0
8
0
8
0
8
0
47
31
8
0
% A
% Cys:
8
8
0
0
0
8
0
0
0
0
0
8
0
0
0
% C
% Asp:
8
0
31
0
31
0
8
8
8
0
0
0
8
31
31
% D
% Glu:
0
0
8
47
0
8
8
16
0
0
8
0
0
8
8
% E
% Phe:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
8
8
8
0
8
0
0
0
8
0
16
8
8
0
0
% G
% His:
0
0
0
0
0
0
8
0
0
0
0
8
0
0
0
% H
% Ile:
0
0
8
0
0
0
8
0
8
8
0
0
0
8
0
% I
% Lys:
8
0
0
0
0
8
0
0
0
0
0
0
0
8
0
% K
% Leu:
0
0
24
8
16
0
62
0
31
54
16
0
16
16
8
% L
% Met:
0
16
0
0
0
8
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
8
0
0
0
0
0
0
0
8
0
0
% N
% Pro:
39
16
0
8
16
8
0
16
31
8
8
0
0
16
0
% P
% Gln:
0
8
8
0
0
8
0
0
0
0
8
16
8
0
0
% Q
% Arg:
0
0
0
0
0
24
0
0
0
8
0
0
0
0
8
% R
% Ser:
24
8
0
8
24
24
0
47
8
16
16
16
8
8
39
% S
% Thr:
0
0
16
8
0
0
8
8
8
0
0
0
16
0
0
% T
% Val:
0
24
0
0
0
0
0
0
0
0
31
0
0
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
0
8
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _